Introduction of Threonine Solution
Threonine is an essential amino acid that the human body can’t produce on its own — it must be obtained through food or supplements. It plays a key role in building proteins, supporting the immune system, and maintaining healthy metabolism.
Today, threonine is mainly produced through advanced microbial fermentation technology, which is efficient, reliable, and environmentally friendly. While other methods like enzymatic and chemical synthesis exist, fermentation has become the industry standard for high-quality threonine production.
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Threonine Production Process
Starch
01
Strain Preparation:
Strain Preparation:
Genetically engineered Escherichia coli or Corynebacterium glutamicum is selected, with its metabolic pathways optimized to increase threonine yield. The strain undergoes slant culture and seed expansion before entering the fermentation stage.
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02
Fermentation Stage
Fermentation Stage
A culture medium is prepared using glucose, corn slurry, ammonium sulfate, potassium dihydrogen phosphate, magnesium sulfate heptahydrate, biotin, and other substances in specific proportions. After sterilization, the pH is maintained at around 7.0, the temperature is controlled at approximately 35°C, and dissolved oxygen levels are kept at 30% during fermentation. The fermentation process lasts 40-50 hours.
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03
Extraction and Purification
Extraction and Purification
After fermentation, bacterial cells and solid impurities are removed from the fermentation broth via centrifugation or filtration. Threonine is then adsorbed using a cation exchange resin and eluted with ammonia water. The crude threonine obtained is dissolved in hot water, the pH is adjusted to the isoelectric point, and the solution is cooled to crystallize. The threonine crystals are separated by centrifugation and dried in a fluidized bed to produce the final product.
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04
Byproduct Treatment
Byproduct Treatment
Bacterial proteins from the fermentation process can be used as feed additives, while the waste liquid, containing inorganic salts and organic residues, requires treatment before discharge or recycling.
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Threonine
Threonine: Product Functions, Applications, and Forms
Product Functions
Protein Synthesis: Threonine is a vital component of proteins, participating in the construction of various proteins.
Immune Function: Supports the production of immunoglobulins and antibodies, enhancing immunity.
Metabolic Regulation: Involved in fat metabolism, helping to maintain liver health.
Nervous System Support: Acts as a precursor to neurotransmitters, positively impacting nervous system function.
Application Areas
Food Industry: Used as a nutritional fortifier in infant formula, health foods, etc.
Feed Industry: Added to animal feed to promote growth and improve feed efficiency.
Pharmaceutical Field: Incorporated into amino acid infusions and nutritional supplements to aid postoperative recovery and support patients with malnutrition.
Cosmetics: Utilized as a moisturizing ingredient in skincare products.
Product Forms
Powder: Suitable for food and feed additives.
Liquid: Used in pharmaceuticals and cosmetics.
Capsules/Tablets: Offered as dietary supplements.
Infant formula milk powder
Feed
Dietary-supplement
Skincare product
Amino Acid Projects
Threonine and Tryptophan Production Project
Threonine and Tryptophan Production Project
Location:
Capacity:
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